Inducible Costimulator Costimulates Cytotoxic Activity and IFN- Production in Activated Murine NK Cells
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Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells.
The functions of NK cells are regulated by the balance of activating and inhibitory signals. The inhibitory NK cell receptors are well understood; however, less is known about the activating signaling pathways. To explore whether a costimulatory receptor, inducible costimulator (ICOS), is involved in NK cell function, we assessed the role of ICOS in NK cell-mediated cytotoxicity and cytokine pr...
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تاریخ انتشار 2002